- Title
- The search for robust topologies of oscillatory gene regulatory networks by evolutionary computation
- Creator
- Komiya, Kazuki; Noman, Nasimul; Iba, Hitoshi
- Relation
- 14th International Conference on Genetic and Evolutionary Computation (GECCO'12). Proceedings of the 14th Annual Conference Companion on Genetic and Evolutionary Computation (Philadelphia, PA 7-11 July, 2012) p. 1419-1420
- Publisher Link
- http://dx.doi.org/10.1145/2330784.2330963
- Publisher
- Association for Computing Machinery (ACM)
- Resource Type
- conference paper
- Date
- 2012
- Description
- Synthetic biology has yielded many successful basic modules inspired by electronic devices over the last ten years. However, there has been very limited success in designing higher order modules by assembling these simpler devices. The lack of robustness in these devices, fails them to work as successful parts in larger system in general. In this paper, we propose a evolutionary search method to construct a robust topology of gene regulatory network in which the concentrations of genes oscillate like a repressilator. This kind of oscillating network works as a "clock" in the biological system and has been in the center of attraction for long. However, the issue of robustness of the designed network remained less attended. Our genetic algorithm evolves oscillating gene regulatory network with a topology superior to other existing topologies in terms of robustness.
- Subject
- synthetic biology; robustness; genetic algorithm; repressilator
- Identifier
- http://hdl.handle.net/1959.13/1057592
- Identifier
- uon:16217
- Identifier
- ISBN:9781450311786
- Language
- eng
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